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- Title
Correlation of Neutrophil CD64 with Clinical Profile and Outcome of Sepsis Patients during Intensive Care Unit Stay.
- Authors
Ghosh, Pralay Shankar; Singh, Harshit; Azim, Afzal; Agarwal, Vikas; Chaturvedi, Saurabh; Saran, Sai; Mishra, Prabhaker; Gurjar, Mohan; Baronia, Arvind Kumar; Poddar, Banani; Singh, Ratender Kumar; Mishra, Ravi
- Abstract
Introduction: Neutrophil CD64 (nCD64) has been found to identify sepsis from nonseptic patients. It is also reported to be a predictor of survival and severity of sepsis. The goal of this study was to correlate serial nCD64 with Intensive Care Unit (ICU) outcome and severity of sepsis. Materials and Methods: A prospective observational study was conducted in 12-bedded critical care unit of a tertiary care center. Adult patients with sepsis were included in this study. Demographics, illness severity scores, clinical parameters, laboratory data, and 28-day outcome were recorded. Serial nCD64 analysis was done (on days 0, 4, and 8) in consecutive patients. Results: Fifty-one consecutive patients were included in the study. Median Acute Physiology and Chronic Health Evaluation II was 16 (12--20) and mean Sequential Organ Failure Assessment was 9 (8--10). Compared to survivors, nonsurvivors had higher nCD64 on day 8 (P = 0.001). nCD64 was higher in the septic shock group compared to sepsis group on days 0 and 8 (P < 0.05). Survivors showed improving trend of nCD64 over time while nonsurvivors did not. This trend was similar in the presence or absence of septic shock. nCD64 count was a good predictor of the septic shock on day 0 (area under the curve [AUC] = 0.747, P = 0.010) and moderate predictor at day 8 (AUC = 0.679, P = 0.028). Conclusion: Monitoring serial nCD64 during ICU stay may be helpful in determining the clinical course of septic patients.
- Subjects
APACHE (Disease classification system); SEPTIC shock; BIOMARKERS; CELL receptors; LENGTH of stay in hospitals; INTENSIVE care units; LONGITUDINAL method; NEUTROPHILS; SCIENTIFIC observation; SURVIVAL; SEPSIS; TREATMENT effectiveness; SEVERITY of illness index; TERTIARY care; PROGNOSIS; DIAGNOSIS
- Publication
Indian Journal of Critical Care Medicine, 2018, Vol 22, Issue 8, p569
- ISSN
0972-5229
- Publication type
Article
- DOI
10.4103/ijccm.IJCCM_228_18