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- Title
Evaluation of anti-inflammatory potential of Pavetta indica Linn. leaf extract (family: Rubiaceae) in rats.
- Authors
Mandal, Subhash C; Mohana Lakshmi, S; Ashok Kumar, C K; Sur, Tapas K; Boominathan, R
- Abstract
The anti-inflammatory potential of methanol extract of Pavetta indica Linn. leaves (Family: Rubiaceae) was evaluated against several models of inflammation such as carragenin, histamine and dextran induced pedal inflammation in rats. The extract showed 48.41%, 41.10% and 24.22% inhibition respectively; when compared to that of control animals. The effect was comparable with that of the standard drug indomethacin, a standard non-steroidal anti-inflammatory drug. Simultaneous subplantar administration of the extract and carrageenin in a mixture helps in differentiating true anti-inflammatory action from an apparent anti-inflammatory effect due to counter-irritant activity. The methanol extract also effectively and significantly reduced cotton pellet induced granuloma. The percentage of inhibition was 62.78 at the dose 500 mg/kg, thereby suggesting its activity in the proliferative phase of the inflammatory process.
- Subjects
THERAPEUTIC use of plant extracts; EDEMA prevention; FOREIGN body reaction; ANIMAL experimentation; COMPARATIVE studies; DEXTRAN; DOSE-effect relationship in pharmacology; EDEMA; HERBAL medicine; HISTAMINE; INDOMETHACIN; LEAVES; RESEARCH methodology; MEDICAL cooperation; NONSTEROIDAL anti-inflammatory agents; ORAL drug administration; PLANTS; POLYSACCHARIDES; RATS; RESEARCH; PLANT extracts; EVALUATION research; PHARMACODYNAMICS; PREVENTION
- Publication
Phytotherapy Research, 2003, Vol 17, Issue 7, p817
- ISSN
0951-418X
- Publication type
journal article
- DOI
10.1002/ptr.1095