We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation.
- Authors
Lin, Qi-Chang; Chen, Li-Da; Yu, Yao-Hua; Liu, Kai-Xiong; Gao, Shao-Yong
- Abstract
Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular morbidity and mortality. However, the underlying mechanism is unclear. In this cross-sectional study, we investigated the influence of OSA on metabolic syndrome (MetS) and inflammation, which were considered as cardiovascular risks. A total of 144 consecutive male patients who underwent standard polysomnography were enrolled. Fasting blood samples were obtained from all patients for glucose, high-sensitivity C-reactive protein (hs-CRP) and lipids measurement. A metabolic score was established as the total number of the positive diagnostic criteria of metabolic syndrome for each patient. Systolic blood pressure, diastolic blood pressure, fasting glucose, hs-CRP and metabolic score significantly increased with the aggravation of OSA severity. Metabolic score increased from 1.74 ± 1.20 to 2.89 ± 0.99 with OSA severity ( p = 0.000). hs-CRP increased from 0.68 (0.43-1.10) to 1.44 (0.62-4.02) mg/L with OSA severity ( p = 0.002). After adjustment for confounders, apnea-hypopnea index and body mass index (BMI) were the major contributing factors for metabolic score ( β = 0.257, p = 0.003 and β = 0.344, p = 0.000, respectively), lowest O saturation and BMI were the independent predictors of hs-CRP ( β = −0.255, p = 0.003 and β = 0.295, p = 0.001, respectively). OSA is independently associated with sum of metabolic components and hs-CRP.
- Subjects
CARDIOVASCULAR diseases risk factors; SLEEP apnea syndromes; METABOLIC syndrome; INFLAMMATION; POLYSOMNOGRAPHY; C-reactive protein; BLOOD pressure; BODY mass index
- Publication
European Archives of Oto-Rhino-Laryngology, 2014, Vol 271, Issue 4, p825
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-013-2669-8