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- Title
Congenital myopathy with mosaic fibers and interlacing sarcomeres: a new structural myopathy.
- Authors
Marbini, A.; Gemignani, F.; Badiali, L.; Bellanova, M. F.; Margarito, F.
- Abstract
A 44-year-old man presenting with dyspnoic attacks was found to be affected with congenital myopathy, rigid spine, restrictive respiratory insufficiency and cardiomyopathy. Muscle biopsy showed type 1 fiber predominance (65.7%) and hypotrophy, and characteristic changes in 43.9% of the type 1 fibers, consisting in alternating pale and dark staining on alkaline ATPase reacted sections in a mosaic pattern. Ultrastructural examination demonstrated bands of myofibrils at right angles or skew to the remaining myofibrils transversing the fibers. Myofibrillar disarray was always associated with loss of the Z-discs and actin filaments, and often with aggregation of mitochondria. The muscle biopsy findings in this patient suggest a new entity of congenital myopathy with clinical features of rigid spine, cardiomyopathy and restrictive respiratory insufficiency, characterized by peculiar abnormalities of ATPase staining in a mosaic pattern and, ultrastructurally, by zones of disorientation of the sarcomeres.
- Publication
Acta Neuropathologica, 1998, Vol 96, Issue 6, p643
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s004010050946