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- Title
Feasibility and Safety of Endoscopic Control for Patients with Serrated Polyposis Syndrome.
- Authors
Nakaoka, Michiko; Chiba, Hideyuki; Kobayashi, Mikio; Okada, Naoya; Arimoto, Jun; Tachikawa, Jun; Ashikari, Keiichi; Kuwabara, Hiroki
- Abstract
Introduction: Despite advances in endoscopic treatment, patients with serrated polyposis syndrome (SPS) occasionally require surgery due to numerous or unresectable polyps, recurrence, and treatment-related adverse events. Methods: We retrospectively evaluated 43 patients with SPS undergoing diagnosis and treatment at Omori Red Cross Hospital from 2011 to 2022. Resection of all polyps ≥3 mm in size was planned during the clearing phase; endoscopic control was defined as complete, endoscopic polyp removal. During the surveillance phase, patients underwent annual colonoscopy and resection of newly detected polyps ≥3 mm in size. Results: Thirty-eight patients (88%) achieved endoscopic control, two (5%) required surgery after endoscopic treatment because of colorectal cancer (CRC), and three (7%) have not yet achieved endoscopic control and are planning treatment. Endoscopic control was achieved with a median of four colonoscopies at 8 months. Ten polyps (median value) were resected per patient during the clearing phase. Three polyps ≥50 mm in size, six located in the appendiceal orifice, and seven with severe fibrosis could be resected by endoscopic submucosal dissection (ESD). All patients underwent treatment with a combination of cold snare polypectomy (CSP), endoscopic mucosal resection/hot polypectomy, and/or ESD. No case required surgery due to difficulty with endoscopic treatment. Delayed bleeding was observed in 2 cases (0.3%). Twenty-one patients underwent colonoscopies during the surveillance phase. Fifty-three polyps were resected using CSP; no CRC, sessile serrated lesions with dysplasia, or advanced adenoma were detected. Conclusion: SPS can be effectively, efficiently, and safely controlled with appropriate endoscopic management.
- Subjects
COLON polyps; ENDOSCOPIC surgery; ADVERSE health care events; SYNDROMES; COLORECTAL cancer; POLYPECTOMY
- Publication
Digestive Diseases, 2024, Vol 42, Issue 1, p31
- ISSN
0257-2753
- Publication type
Article
- DOI
10.1159/000534968