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- Title
Characteristics of post-transcriptional gene silencing.
- Authors
Chicas, Agustin; Macino, Giuseppe
- Abstract
A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and discuss the possible biological roles of these artificially induced phenomena. We also discuss other features of PTGS such as the mechanism of mRNA degradation, the nature of the silencing signal and the mechanism of PTGS inhibition by viral proteins.
- Subjects
GENE silencing; GENES; PROTEINS; VIRAL proteins; BIOMOLECULES; BIOLOGY
- Publication
EMBO Reports, 2001, Vol 2, Issue 11, p992
- ISSN
1469-221X
- Publication type
Article
- DOI
10.1093/embo-reports/kve231