We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus.
- Authors
Stalenhoef, J. E.; Alisjahbana, B.; Nelwan, E. J.; van der Ven-Jongekrijg, J.; Ottenhoff, T. H. M.; Meer, J. W. M.; Nelwan, R. H.; Netea, M. G.; van Crevel, R.
- Abstract
As patients with diabetes mellitus are at increased risk of developing tuberculosis, we hypothesized that this susceptibility to mycobacterial infection is due to a defective Th1-cytokine response. To explore this hypothesis, we examined four groups of subjects in Indonesia: 23 patients with tuberculosis, 34 patients with tuberculosis and diabetes, 32 patients with diabetes only and 36 healthy controls. Ex-vivo production of interferon (IFN)γ, tumour necrosis factor-α and interleukin (IL)-1β, 6, 10, -12 and -4 was measured following stimulation with Mycobacterium tuberculosis, Escherichia coli lipopolysaccharide and phytohaemagglutinin. Patients with active tuberculosis were found to have lower IFNγ levels and a higher production of other pro-inflammatory cytokines and IL-4, both in the presence and absence of diabetes. Diabetes patients without tuberculosis, however, showed strongly reduced non-specific IFNγ production, which is essential for inhibition of the initial growth of M. tuberculosis. Our data suggest that a defective non-specific immune response in diabetes may contribute to an increased susceptibility to develop tuberculosis.
- Subjects
PEOPLE with diabetes; INTERFERONS; TUBERCULOSIS; TYPE 2 diabetes; MYCOBACTERIAL diseases; CYTOKINES; TUMOR necrosis factors; INTERLEUKIN-1; MYCOBACTERIUM tuberculosis
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2008, Vol 27, Issue 2, p97
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-007-0395-0