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- Title
Oxidative Stress-Induced Protein of SESTRIN2 in Cardioprotection Effect.
- Authors
Rongjin, Huang; Feng, Chen; Jun, Ke; Shirong, Lin
- Abstract
Because of the rich mitochondria and high energy metabolic requirements, excessive oxidative stress generated by ROS is a key pathogenic mechanism in heart disease. SESTRIN2, the well-known antioxidant protein, plays a vital role in diminishing the production and accumulation of ROS, thus sparing cells from oxidative damage. From this new perspective, we first examine SESTRIN2 structure-function relationships; then, we describe how SESTRIN2 expression is regulated under oxidative stress conditions, emphasizing SESTRIN2's antioxidant mechanism via multiple signal transductions; and finally, we discuss SESTRIN2's role in a variety of oxidative stress-related cardiac diseases, including age-related heart disease, diabetic cardiomyopathy, ischemia-reperfusion myocardial injury, septic cardiomyopathy, and chronic cardiac insufficiency. The goal of this review is to identify the SESTRIN2 protein as a potential biomarker and new therapy target for oxidative stress-related cardiac diseases.
- Subjects
HEART failure; MYOCARDIAL injury; HEART diseases; DIABETIC cardiomyopathy; REPERFUSION injury; MYOCARDIAL reperfusion
- Publication
Disease Markers, 2022, p1
- ISSN
0278-0240
- Publication type
Article
- DOI
10.1155/2022/7439878