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- Title
Endometrial Stem/Progenitor Cells: Prospects and Challenges.
- Authors
Gargett, Caroline E.; Hapangama, Dharani
- Abstract
New technologies and concepts including single-cell sequencing, somatic mutations, endometrial histoarchitecture and organoid models open different avenues to further understand the roles of endometrial stem/progenitor cells in endometrial dynamics and endometrial pathologies. One review has explored the role of currently identified endometrial stem/progenitor cells and bone-marrow-derived cells in establishing endometriosis lesions, taking into account the theories of endometriosis pathogenesis [[5]]. Organoids have been derived from endometriotic lesions, and their co-culture with eMSCs, together with single-cell transcriptional and somatic mutation profiling in future studies, would clarify the role of endometrial stem/progenitor cells in endometriosis [[4]]. SP cells are also candidates, as they contain both epithelial and stromal cells with stem/progenitor cell properties [[5]].
- Subjects
PROGENITOR cells; ENDOMETRIUM; ENDOMETRIOSIS; CYTOLOGY; ASHERMAN'S syndrome; EPITHELIAL cells; RECURRENT miscarriage
- Publication
Journal of Personalized Medicine, 2022, Vol 12, Issue 9, pN.PAG
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm12091466