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- Title
Antinociceptive Potential of Viscosine Isolated form Dodonaea viscosa in Animal Models.
- Authors
Zada Khan, Amir; Muhammad, Akhter; Anis, Itrat; Iqbal, Zafar; Raza Shah, Muhammad; Khan, Inamullah; Muhammad, Naveed; Ali Shah, Syed Uzair; Farooq, Umar; Khan, Ajmal
- Abstract
Dodonaea viscosa was selected in this study based on its ethno-medicinal applications for treating various painful conditions. In earlier studies crude extracts of Dodonaea viscosa showed significant actions as local anesthetic, smooth muscle relaxant, antibacterial, anti-inflammatory, antifungal, anti-ulcerogenic, anti-ascariasis, anthelmintic, cardiac depressant, hypotensive, uterine relaxation and vasoconstrictor activity in different experimental models. In an effort to identify the potential analgesic components of the plant, the principal flavonoid constituent, 5,7,4'-trihydroxy-3,6-dimethoxyflavone (viscosine) was isolated. When tested using the acetic acid-induced writhing and hot plate analgesic models, viscosine (30, 45 and 60 mg/kg), showed significant (p < 0.05) antinociceptive activity in a dose-dependent manner. It is concluded that viscosine has antinociceptive therapeutic potential through both central and peripheral mechanisms and can be used a template compound as a painkiller.
- Subjects
ANALGESICS; DODONAEA; PLANT extracts; FLAVONOIDS; ACETIC acid; MEDICINAL plants
- Publication
Journal of the Chemical Society of Pakistan, 2014, Vol 36, Issue 6, p1150
- ISSN
0253-5106
- Publication type
Article