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- Title
Oestrogen induced suppression of collagen arthritis: I. Long term oestradiol treatment of DBA/1 mice reduces severity and incidence of arthritis and decreases the anti type II collagen immune response.
- Authors
Holmdahl, R.; Jonsson, Liselotte; Meyerson, B.; Klareskog, L.
- Abstract
Experimental animal models can be used to help understand how oestrogen modulates autoimmune arthritis. We have previously shown that castration of female DBA/1 mice exaggerates arthritis induced with type II collagen. This report shows that treatment of castrated DBA/1 mice with low doses (0.2 μg twice a week) of β-oestradiol reduces the incidence (37%, vs78% in controls) and severity (3.9 vs 5.6 mean scores) of arthritis. Levels of IgG anti type II collagen antibodies are decreased whereas levels of IgM antibodies are increased in the β-oestradiol treated mice. The T cell response, as measured by a ³H-thymidine assay,, is reduced in the β-oestradiol treated mice. The results suggest that treatment with low doses of β-oestradiol exerts a suppressive effect on both development of collagen arthritis as well as T cell dependent immune reactivity towards type II collagen.
- Subjects
ESTRADIOL; ESTROGEN; CONNECTIVE tissues; JOINT diseases; ARTHRITIS; STEROID hormones
- Publication
Clinical & Experimental Immunology, 1987, Vol 70, Issue 2, p372
- ISSN
0009-9104
- Publication type
Article