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- Title
HLA-DR antigen expression on T cells from cerebrospinal fluid in multiple sclerosis and aseptic meningo-encephalitis.
- Authors
Fredrikson, S.; Karlsson-Parra, A.; Olsson, T.; Link, H.
- Abstract
HLA-DR expression on T lymphocytes in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) and acute aseptic meningo-encephalitis (AM), and from blood only from healthy controls was examined by a new double-immunofluorescence labelling assay using species-specific second layers on prefixed cell samples. Thirteen of 16 patients with AM (81%) had an elevated percentage of DR positive T cells in CSF against only two of 20 patients with MS (10%). Our data indicate that AM, an acute infection of the central nervous system (CNS), is accompanied by accumulation in CSF of activated, DR positive T cells as a reflection of actively involved cellular immunity within the CNS, while this accumulation of DR positive T cells is not seen in MS, a chronic inflammatory CNS disease, despite some of the patients being examined during clinical exacerbations.
- Subjects
ANTIGENS; CEREBROSPINAL fluid; MULTIPLE sclerosis; T cells; NERVOUS system; IMMUNOCYTOCHEMISTRY
- Publication
Clinical & Experimental Immunology, 1987, Vol 68, Issue 2, p298
- ISSN
0009-9104
- Publication type
Article