We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Oral Targeted Therapies and Central Nervous System (CNS) Metastases.
- Authors
Gabay, Michael; Wirth, Scott; Stachnik, Joan; Overley, Colleen; Long, Katie; Bressler, Linda; Villano, John; Gabay, Michael P; Wirth, Scott M; Stachnik, Joan M; Overley, Colleen L; Long, Katie E; Bressler, Linda R; Villano, John L
- Abstract
The purpose of our review is to summarize the clinical activity of oral targeted agents against brain metastases. This includes BRAF inhibitors (dabrafenib and vemurafenib), human epidermal growth factor receptor inhibitors (lapatinib, gefitinib, erlotinib, and afatinib), multi-kinase angiogenesis inhibitors (sorafenib, sunitinib, pazopanib, and vandetanib), and ALK/c-MET (crizotinib) and ALK/IGF-1 (ceritinib) inhibitors. Effective systemic therapies are needed for long-term benefit in brain metastases and documentation of intracranial activity for many therapies is poor. Our review provides a summary of the literature with pertinent data for clinicians. This is needed as subjects with brain metastases are often prevented from enrolling in clinical trials and investigations focused on systemic therapies for brain metastases are rare.
- Subjects
CENTRAL nervous system diseases; THERAPEUTICS; BRAIN metastasis; EPIDERMAL growth factor receptors; CEREBROSPINAL fluid; CLINICAL trials; TREATMENT effectiveness; ANTINEOPLASTIC agents; BRAIN tumors; ORAL drug administration
- Publication
CNS Drugs, 2015, Vol 29, Issue 11, p935
- ISSN
1172-7047
- Publication type
journal article
- DOI
10.1007/s40263-015-0283-6