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- Title
Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis.
- Authors
Seiti Yamada Yoshikawa, Fabio; Feitosa de Lima, Josenilson; Notomi Sato, Maria; Álefe Leuzzi Ramos, Yasmin; Aoki, Valeria; Leao Orfali, Raquel
- Abstract
Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.
- Subjects
ATOPIC dermatitis; STAPHYLOCOCCUS aureus; STAPHYLOCOCCUS; TOXINS; NATURAL immunity; SKIN diseases
- Publication
Toxins, 2019, Vol 11, Issue 6, p321
- ISSN
2072-6651
- Publication type
Article
- DOI
10.3390/toxins11060321