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- Title
A Biphasic Hydrogel with Self-Healing Properties and a Continuous Layer Structure for Potential Application in Osteochondral Defect Repair.
- Authors
Jiang, Yue; Guo, Shanzhu; Jiao, Jingjing; Li, Long
- Abstract
The treatment of osteochondral defects remains challenging due to the limited healing capacity of cartilage and the poor results of traditional methods. Inspired by the structure of natural articular cartilage, we have fabricated a biphasic osteochondral hydrogel scaffold using a Schiff base reaction and a free radical polymerization reaction. Carboxymethyl chitosan (CMCS), oxidized sodium alginate (OSA), and polyacrylamide (PAM) formed a hydrogel (COP) as the cartilage layer, while hydroxyapatite (HAp) was incorporated into the COP hydrogel to obtain a hydrogel (COPH) as an subchondral bone layer. At the same time, hydroxyapatite (HAp) was incorporated into the COP hydrogel to obtain a hydrogel (COPH) as an osteochondral sublayer, combining the two to obtain an integrated scaffold for osteochondral tissue engineering. Interlayer interpenetration through the continuity of the hydrogel substrate and good self-healing properties due to the dynamic imine bonding of the hydrogel resulted in enhanced interlayer bond strength. In addition, in vitro experiments have shown that the hydrogel exhibits good biocompatibility. It shows great potential for osteochondral tissue engineering applications.
- Subjects
FREE radical reactions; ARTICULAR cartilage; HYDROXYAPATITE; TISSUE scaffolds; SCHIFF bases; HYDROGELS; TISSUE engineering; POLYACRYLAMIDE
- Publication
Polymers (20734360), 2023, Vol 15, Issue 12, p2744
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym15122744