We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fabrication of Curcumin Diethyl γ-Aminobutyrate-Loaded Chitosan-Coated Magnetic Nanocarriers for Improvement of Cytotoxicity against Breast Cancer Cells.
- Authors
Hansapaiboon, Supakarn; Bulatao, Bryan Paul; Sorasitthiyanukarn, Feuangthit Niyamissara; Jantaratana, Pongsakorn; Nalinratana, Nonthaneth; Vajragupta, Opa; Rojsitthisak, Pranee; Rojsitthisak, Pornchai
- Abstract
This study shows the effectiveness of magnetic-guide targeting in the delivery of curcumin diethyl γ-aminobutyrate (CUR-2GE), a prodrug of curcumin (CUR) previously synthesized to overcome unfavorable physicochemical properties of CUR. In this study, chitosan (Ch)-coated iron oxide nanoparticles (Ch-IONPs) were fabricated and optimized using Box–Behnken design-based response surface methodology for delivery of CUR-2GE. Ch was used as a coating material on the nanoparticle surface to avoid aggregation. The optimized condition for preparing Ch-IONPs consisted of using 4 mg Ch fabricated at pH 11 under a reaction temperature of 85 °C. The optimized Ch-IONPs were successfully loaded with CUR-2GE with sufficient loading capacity (1.72 ± 0.01%) and encapsulation efficiency (94.9 ± 0.8%). The obtained CUR-2GE-loaded Ch-IONPs (CUR-2GE-Ch-IONPs) exhibited desirable characteristics including a particle size of less than 50 nm based on TEM images, superparamagnetic property, highly crystalline IONP core, sufficient stability, and sustained-release profile. In the presence of permanent magnets, CUR-2GE-Ch-IONPs significantly increased cellular uptake and cytotoxicity toward MDA-MB-231 with a 12-fold increase in potency compared to free CUR-2GE, indicating the potential of magnetic-field assisted delivery of CUR-2GE-Ch-IONPs for the treatment of triple-negative breast cancer.
- Subjects
CURCUMIN; IRON oxide nanoparticles; BREAST cancer; SUPERPARAMAGNETIC materials; TRIPLE-negative breast cancer; NANOCARRIERS; CANCER cells; CHITOSAN
- Publication
Polymers (20734360), 2022, Vol 14, Issue 24, p5563
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym14245563