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- Title
Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications.
- Authors
Maiz-Fernández, Sheila; Pérez-Álvarez, Leyre; Ruiz-Rubio, Leire; Vilas-Vilela, Jose Luis; Lanceros-Mendez, Senentxu
- Abstract
In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.
- Subjects
HYDROGELS; TISSUE engineering; COVALENT bonds; INDIVIDUALIZED medicine; REGENERATIVE medicine
- Publication
Polymers (20734360), 2020, Vol 12, Issue 10, p2261
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym12102261