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- Title
Control of bone and fat mass by oxytocin.
- Authors
Amri, Ez-Zoubir; Pisani, Didier F.
- Abstract
Osteoporosis and overweight/obesity constitute major worldwide public health burdens. Aging is associated with a decrease in hormonal secretion, lean mass and bone mass, and an increase in fat accumulation. It is established that both obesity and osteoporosis are affected by genetic and environmental factors, bone remodeling and adiposity are both regulated through the hypothalamus and sympathetic nervous system. Oxytocin (OT), belongs to the pituitary hormone family and regulates the function of peripheral target organs, its circulating levels decreased with age. Nowadays, it is well established that OT plays an important role in the control of bone and fat mass and their metabolism. Of note, OT and oxytocin receptor knock out mice develop bone defects and late-onset obesity. Thus OT emerges as a promising molecule in the treatment of osteoporosis and obesity as well as associated metabolic disorders such as type 2 diabetes and cardiovascular diseases. In this review, we will discuss findings regarding the OT effects on bone and fat mass.
- Subjects
OXYTOCIN; OBESITY; OSTEOPOROSIS; OSTEOBLASTS; PHYSIOLOGICAL aspects of aging; THERAPEUTICS
- Publication
Hormone Molecular Biology & Clinical Investigation, 2016, Vol 28, Issue 2, p95
- ISSN
1868-1883
- Publication type
Article
- DOI
10.1515/hmbci-2016-0045