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- Title
Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly.
- Authors
Novaković, Romana; Geelen, Anouk; Ristić-Medić, Danijela; Nikolić, Marina; Souverein, Olga W.; McNulty, Helene; Duffy, Maresa; Hoey, Leane; Dullemeijer, Carla; Renkema, Jacoba M.S.; Gurinović, Mirjana; Glibetić, Marija; de Groot, Lisette C.P.G.M.; van’t Veer, Pieter
- Abstract
<bold>Background:</bold> Dietary reference values for folate intake vary widely across Europe. <bold>Methods:</bold> MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. <bold>Results:</bold> For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). <bold>Conclusion:</bold> These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.
- Subjects
ERYTHROCYTES; BIOMARKERS; CONFIDENCE intervals; DOSE-response relationship in biochemistry; FOLIC acid; MEDICAL information storage &; retrieval systems; INGESTION; MEDLINE; META-analysis; SCIENTIFIC observation; REFERENCE values; REGRESSION analysis; HOMOCYSTEINE; SYSTEMATIC reviews
- Publication
Annals of Nutrition & Metabolism, 2018, Vol 73, Issue 1, p30
- ISSN
0250-6807
- Publication type
Article
- DOI
10.1159/000490003