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- Title
Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder.
- Authors
Shirahama, Tsutomu; Arima, Jun-ichirou; Akiba, Suminori; Sakakura, Chohei; Shirahama, T; Arima, J; Akiba, S; Sakakura, C
- Abstract
<bold>Background: </bold>Expression of the inducible form of cyclooxygenase (COX)-2 is known to correlate with development of transitional cell carcinoma (TCC) of the human urinary bladder. However, the clinical significance of COX-2 expression with respect to clinicopathologic findings and patient survival is unknown.<bold>Methods: </bold>COX-2 expression was examined immunohistochemically in tumor tissues obtained from 108 patients who underwent radical cystectomy for TCCs, without knowledge of clinicopathologic findings. Correlation between COX-2 expression and clinicopathologic findings and patient survival was determined.<bold>Results: </bold>COX-2 expression was detected in 34 of 108 (31%) tumors but in none of 10 normal uroepithelial samples. Univariate logistic regression analysis showed a significant correlation between COX-2 expression and local invasion, infiltration pattern, lymphatic invasion, and venous invasion. However, multivariate logistic regression analysis revealed that only local invasion correlated significantly with COX-2 expression (P = 0.047). Cox proportional hazards regression analysis showed that both local invasion (P = 0.008) and lymph node metastasis (P = 0.001) were independent prognostic factors; however, COX-2 expression (P = 0.16) was not.<bold>Conclusions: </bold>The authors showed that COX-2 overexpression plays a role in development and invasion of TCCs, but not prognosis of patients with TCC. COX-2 inhibitors may be useful for chemoprevention of TCCs and treatment of invasive disease.
- Publication
Cancer (0008543X), 2001, Vol 92, Issue 1, p188
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(20010701)92:1<188::AID-CNCR1308>3.0.CO;2-W