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- Title
MHO_0730 as a Surface-Exposed Calcium-Dependent Nuclease of Mycoplasma hominis Promoting Neutrophil Extracellular Trap Formation and Escape.
- Authors
Cacciotto, Carla; Dessì, Daniele; Cubeddu, Tiziana; Cocco, Anna Rita; Pisano, Andrea; Tore, Gessica; Fiori, Pier Luigi; Rappelli, Paola; Pittau, Marco; Alberti, Alberto; Rapelli, Paola
- Abstract
Mycoplasma lipoproteins play a relevant role in pathogenicity and directly interact with the host immune system. Among human mycoplasmas, Mycoplasma hominis is described as a commensal bacterium that can be associated with a number of genital and extragenital conditions. Mechanisms of M. hominis pathogenicity are still largely obscure, and only a limited number of proteins have been associated with virulence. The current study focused on investigating the role of MHO_0730 as a virulence factor and demonstrated that MHO_0730 is a surface lipoprotein, potentially expressed in vivo during natural infection, acting both as a nuclease with its amino acidic portion and as a potent inducer of Neutrophil extracellular trapsosis with its N-terminal lipid moiety. Evidence for M. hominis neutrophil extracellular trap escape is also presented. Results highlight the relevance of MHO_0730 in promoting infection and modulation and evasion of innate immunity and provide additional knowledge on M. hominis virulence and survival in the host.
- Subjects
MYCOPLASMA; NATURAL immunity; MYCOPLASMATALES; ESCAPES; IMMUNE system
- Publication
Journal of Infectious Diseases, 2019, Vol 220, Issue 12, p1999
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiz406