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- Title
Bivalent Human Papillomavirus (HPV) Vaccine Effectiveness Correlates With Phylogenetic Distance From HPV Vaccine Types 16 and 18.
- Authors
Bogaards, Johannes A; van der Weele, Pascal; Woestenberg, Petra J; Benthem, Birgit H B van; King, Audrey J; van Benthem, Birgit H B
- Abstract
To substantiate cross-protection reported across AS04-adjuvanted bivalent human papillomavirus (HPV) vaccine (2vHPV) studies, we reevaluated vaccine effectiveness against type-specific HPV positivity as a function of phylogenetic distance to vaccine target types HPV-16 and -18. We provide evidence of sustained cross-protection up to 8 years postvaccination in a high-risk population in the Netherlands. Moreover, our findings suggest that genomic distance better explains cross-protection than distance measures based on capsid antigens only. Taken together, 2vHPV is predicted to provide partial cross-protection against HPV-31, -33, -35, -45, -52, and possibly -58, that is, acknowledged oncogenic types with close phylogenetic relationships to HPV-16 or -18.
- Subjects
NETHERLANDS; PAPILLOMAVIRUSES; VACCINE effectiveness; VACCINES; DISTANCES; COMPARATIVE studies; BIOLOGICAL evolution; IMMUNITY; RESEARCH methodology; MEDICAL cooperation; PAP test; PAPILLOMAVIRUS diseases; POLYMERASE chain reaction; PROTEINS; RESEARCH; HUMAN papillomavirus vaccines; EVALUATION research; TREATMENT effectiveness; CROSS-sectional method; GENOTYPES
- Publication
Journal of Infectious Diseases, 2019, Vol 220, Issue 7, p1141
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiz280