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- Title
Long-term Bone Mineral Density Changes in Antiretroviral-Treated HIV-Infected Individuals.
- Authors
Grant, Philip M.; Kitch, Douglas; McComsey, Grace A.; Collier, Ann C.; Koletar, Susan L.; Erlandson, Kristine M.; Yin, Michael T.; Bartali, Benedetta; Ha, Belinda; Melbourne, Kathy; Brown, Todd T.
- Abstract
We compared adjusted bone mineral density (BMD) changes between human immunodeficiency virus (HIV)-infected individuals during the first approximately 7.5 years after antiretroviral therapy (ART) initiation and HIV-uninfected controls. HIV-infected individuals (n = 97) had significantly greater adjusted BMD decline than controls (n = 614) during the first 96 weeks of ART. Subsequently, the rate of BMD decline slowed in HIV-infected individuals but remained greater than the rate of decline in HIV-uninfected individuals at the lumbar spine but not at the hip. In HIV-infected individuals after 96 weeks, no HIV- or treatment-related characteristic was associated with BMD loss, but lower lean body mass was associated with greater BMD loss at both lumbar spine and hip.
- Subjects
BONE density; HIV infections; ANTIRETROVIRAL agents; LUMBAR vertebrae; BODY mass index
- Publication
Journal of Infectious Diseases, 2016, Vol 214, Issue 4, p607
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw204