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- Title
Serotype-Specific Cell-Mediated Immunity Associated With Clearance of Homotypic Group B Streptococcus Rectovaginal Colonization in Pregnant Women.
- Authors
Kwatra, Gaurav; Adrian, Peter V.; Shiri, Tinevimbo; Izu, Alane; Cutland, Clare L.; Buchmann, Eckhart J.; Madhi, Shabir A.
- Abstract
We investigated the association between group B Streptococcus (GBS) serotype-specific capsular polysaccharide cellular immunity, measured with enzyme-linked immunospot (ELISPOT) interferon γ release assay at 20 weeks gestation in pregnant women, and its effect on rectovaginal serotype-specific GBS colonization up to 37 weeks gestation. Among women colonized by serotype III at enrollment, interferon γ ELISPOT positivity was more common in those in whom colonization was cleared (44.4%) than in those in whom colonization persisted (7.4%; P = .008), with a similar trend observed for serotype Ia. Presence of serotype-specific capsular polysaccharide cell-mediated immunity contributes to the clearance of GBS rectovaginal colonization.
- Subjects
STREPTOCOCCUS agalactiae; RECTOVAGINAL fistula; CELLULAR immunity; MATERNAL health; SEROTYPES; POLYSACCHARIDES; BACTERIAL physiology; BACTERIAL antigens; COMMUNICABLE diseases; PREGNANCY complications; RECTUM; STREPTOCOCCAL diseases; STREPTOCOCCUS; VAGINA
- Publication
Journal of Infectious Diseases, 2016, Vol 213, Issue 12, p1923
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw056