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- Title
Simplified quantification of <sup>13</sup>N-ammonia PET myocardial blood flow: A comparative study with the standard compartment model to facilitate clinical use.
- Authors
Chang, Chih-Yung; Hung, Guang-Uei; Hsu, Bailing; Yang, Bang-Hung; Chang, Chi-Wei; Hu, Lien-Hsin; Huang, Wen-Sheng; Wang, Hsin-Ell; Wu, Tao-Cheng; Liu, Ren-Shyan
- Abstract
<bold>Background: </bold>Short imaging protocol to quantify myocardial blood flow (MBF) and myocardial flow reserve (MFR) may enhance the clinical application of 13N-ammonia cardiac PET. We assessed the flow quantitation of 13N-ammonia PET implementing simple retention model and two-compartment model.<bold>Methods: </bold>Fourteen healthy volunteers (HVT) and twenty-three clinical patients received 13N-ammonia PET/CT. The simple retention model used the first 7-minute image to quantify MBF. Global and regional MBF and MFR of the two models were compared.<bold>Results: </bold>Global and regional MBF and MFR of these two models were highly correlated with mildly inferior correlation in RCA territory (global R2: rest MBF = 0.79, stress MBF = 0.65, MFR = 0.77; regional R2: rest MBF ≥ 0.72, stress MBF ≥ 0.52, MFR ≥ 0.68). There were significant differences for MFR (4.04 ± 0.72, 3.66 ± 0.48, p = .02) and rest MBF (0.69 ± 0.12, 0.78 ± 0.12, p = .02) between the two models in the HVT group.<bold>Conclusions: </bold>13N-ammonia global and regional MBF and MFR from the simple retention model demonstrate strong correlations with that from the two-compartment model. Significant differences of MFR and rest MBF are noted in the HVT group, with a proposed normal reference value for the 13N-ammonia short simple retention protocol.
- Subjects
BLOOD flow; COMPARATIVE studies; DIGITAL image processing; RESEARCH; MYOCARDIUM; HEART; AMMONIA; ARTERIES; RESEARCH methodology; RADIOISOTOPES; MEDICAL cooperation; EVALUATION research; CORONARY circulation; CORONARY artery disease; HEART function tests; RADIOPHARMACEUTICALS; MENTAL health surveys
- Publication
Journal of Nuclear Cardiology, 2020, Vol 27, Issue 3, p819
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1007/s12350-018-1450-1