We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Efficacy of nivolumab in pre-treated non-small-cell lung cancer patients harbouring KRAS mutations.
- Authors
Passiglia, Francesco; Cappuzzo, Federico; Alabiso, Oscar; Bettini, Anna Cecilia; Bidoli, Paolo; Chiari, Rita; Defferrari, Carlotta; Delmonte, Angelo; Finocchiaro, Giovanna; Francini, Guido; Gelsomino, Francesco; Giannarelli, Diana; Giordano, Monica; Illiano, Alfonso; Livi, Lorenzo; Martelli, Olga; Natoli, Clara; Puppo, Gianfranco; Ricevuto, Enrico; Roca, Elisa
- Abstract
<bold>Background: </bold>The present study investigated the efficacy and safety of nivolumab in pre-treated patients with advanced NSCLC harbouring KRAS mutations.<bold>Methods: </bold>Clinical data and KRAS mutational status were analysed in patients treated with nivolumab within the Italian Expanded Access Program. Objective response rate, progression-free survival and overall survival were evaluated. Patients were monitored for adverse events using the National Cancer Institute Common Terminology Criteria for Adverse Events.<bold>Results: </bold>Among 530 patients evaluated for KRAS mutations, 206 (39%) were positive while 324 (61%) were KRAS wild-type mutations. KRAS status did not influence nivolumab efficacy in terms of ORR (20% vs 17%, P = 0.39) and DCR (47% vs 41%, P = 0.23). The median PFS and OS were 4 vs 3 months (P = 0.5) and 11.2 vs 10 months (P = 0.8) in the KRAS-positive vs the KRAS-negative group. The 3-months PFS rate was significantly higher in the KRAS-positive group as compared to the KRAS-negative group (53% vs 42%, P = 0.01). The percentage of any grade and grade 3-4 AEs were 45% vs 33% (P = 0.003) and 11% vs 6% (P = 0.03) in KRAS-positive and KRAS-negative groups, respectively.<bold>Conclusions: </bold>Nivolumab is an effective and safe treatment option for patients with previously treated, advanced non-squamous NSCLC regardless of KRAS mutations.
- Publication
British Journal of Cancer, 2019, Vol 120, Issue 1, p57
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-018-0234-3