We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers.
- Authors
Kim, Chang Gon; Ahn, Joong Bae; Jung, Minkyu; Beom, Seung Hoon; Kim, Chan; Kim, Joo Hoon; Heo, Su Jin; Park, Hyung Soon; Kim, Jee Hung; Kim, Nam Kyu; Min, Byung Soh; Kim, Hoguen; Koom, Woong Sub; Shin, Sang Joon
- Abstract
<bold>Background: </bold>Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs.<bold>Methods: </bold>This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed.<bold>Results: </bold>A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results.<bold>Conclusions: </bold>Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.
- Subjects
CANCER relapse; COLON tumors; DEGENERATION (Pathology); DNA; PROGNOSIS; RECTUM tumors; PROPORTIONAL hazards models
- Publication
British Journal of Cancer, 2016, Vol 115, Issue 1, p25
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/bjc.2016.161