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- Title
The role of iodine-131 and thallium-201 imaging and serum thyroglobulin in the management of differentiated thyroid carcinoma.
- Authors
Dadparvar, Simin; Krishna, Lalitha; Brady, Luther W.; Slizofski, Walter J.; Brown, Steven J.; Chevres, Anita; Micaily, Bizhan; Dadparvar, S; Krishna, L; Brady, L W; Slizofski, W J; Brown, S J; Chevres, A; Micaily, B
- Abstract
<bold>Background: </bold>A prospective study was conducted to evaluate the use of iodine-131 sodium scintigraphy, thallium-201 chloride scintigraphy, and quantitative serum thyroglobulin estimation in the detection of differentiated thyroid carcinoma after thyroidectomy and iodine-131 sodium ablative therapy.<bold>Methods: </bold>Thirty-one patients with a median age of 45.6 years (range, 20-73 years) were included in the study. After optimal endogenous thyroid-stimulating hormone stimulation (> 50 mU/ml), 53 pairs of iodine-131 and thallium-201 scans were performed. Concomitant serum thyroglobulin levels were available for 32 pairs of scans. The presence or absence of thyroid cancer was established by clinical, radiologic, and/or biopsy findings.<bold>Results: </bold>The concordance between iodine-131 and thallium-201 scan findings in the presence of disease (25 scan sets) was 36%. The concordance in the absence of disease (28 scan sets) was 82%. Iodine-131 scanning was found to be significantly better (P < 0.05) than thallium-201 scanning, in terms of sensitivity (0.8 versus 0.6), specificity (0.96 versus 0.82), accuracy (0.89 versus 0.72), and the predictive value of a positive test (0.95 versus 0.75). The measurement of serum thyroglobulin had a low sensitivity (0.3) in the study but had a specificity of 1.0.<bold>Conclusion: </bold>It was concluded that iodine-131 sodium scintigraphy is superior to thallium-201 scintigraphy and serum thyroglobulin estimation for the detection of residual or metastatic differentiated thyroid carcinoma. However, the use of combined modalities provides a higher diagnostic yield. Thallium-201 scintigraphy was especially useful in cases in which iodine-131 scintigraphy was negative and quantitative thyroglobulin levels were elevated.
- Publication
Cancer (0008543X), 1993, Vol 71, Issue 11, p3767
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19930601)71:11<3767::AID-CNCR2820711146>3.0.CO;2-W