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- Title
Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection.
- Authors
Joseph, Sarah; Jones, Frances M.; Laidlaw, Maureen E.; Mohamed, Gamal; Mawa, Patrice A.; Namujiu, Proscovia B.; Kizza, Moses; Watera, Christine; Whitworth, James A.G.; Dunne, David W.; Elliott, Alison M.; Namujju, Proscovia B
- Abstract
We show that Ugandan adults coinfected with Schistosoma mansoni and human immunodeficiency virus type 1 (HIV-1) are able to mount S. mansoni-specific immune responses but that few such responses increase after treatment with praziquantel (PZQ). Levels of soluble worm antigen (SWA)-specific immunoglobulin (Ig) G1, IgG2, IgG3, IgG4, interleukin (IL)-4, and IL-5 increased significantly in HIV-negative participants after treatment with PZQ, whereas most soluble egg antigen-specific antibody responses and levels of interferon- gamma were unaltered. Only levels of SWA-specific IL-5 increased in HIV-1-coinfected participants after treatment. These deficiencies in immune responses may account for the previously reported increased susceptibility to infection and reinfection with S. mansoni in individuals coinfected with HIV-1.
- Subjects
UGANDA; SCHISTOSOMA mansoni; IMMUNE response; HIV infections; HIV-positive persons; IMMUNOGLOBULINS; HIV infection complications; ANTHELMINTICS; ISOQUINOLINE; ANIMAL experimentation; ANTIGENS; COMPARATIVE studies; CYTOKINES; HIV; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SCHISTOSOMIASIS; TREMATODA; EVALUATION research; DISEASE complications; THERAPEUTICS
- Publication
Journal of Infectious Diseases, 2004, Vol 190, Issue 3, p613
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/422396