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- Title
Long-Cycle Structured Intermittent versus Continuous Highly Active Antiretroviral Therapy for the Treatment of Chronic Infection with Human Immunodeficiency Virus: Effects on Drug Toxicity and on Immunologic and Virologic Parameters.
- Authors
Dybul, Mark; Nies-Kraske, Elizabeth; Daucher, Marybeth; Hertogs, Kurt; Hallahan, Claire W.; Csako, Gyorgy; Yoder, Christian; Ehler, Linda; Sklar, Peter A.; Belson, Michael; Hidalgo, Bertha; Metcalf, Julia A.; Davey, Richard T.; Kress, Diane M. Rock; Powers, April; Fauci, Anthony S.
- Abstract
We evaluated the effect of long-cycle structured intermittent therapy (SIT; 4 weeks without highly active antiretroviral therapy [HAART] followed by 8 weeks with HAART) versus continuous HAART. The study was prematurely terminated to new enrollment because of the emergence of genetic mutations associated with resistance to antiretroviral drugs in 5 patients. After 48 weeks, there was no significant difference between groups in lipid, hepatic transaminase, and C-reactive protein levels in 41 patients. Although there were no differences in CD4[sup +] or CD8[sup +] T cell counts or the percentage of cells that were CD4[sup +]CD25[sup +], CD8[sup +]CD25[sup +], or CD4[sup +]DR[sup +], patients who received SIT had a significantly higher percentage of CD8[sup +]CD38[sup +] and CD8[sup +]DR[sup +] cells. There was no clear autoimmunization effect by immunologic or virologic parameters. There was no benefit to long-cycle SIT versus continuous HAART with regard to certain toxicity, immunologic, or virologic parameters.
- Subjects
ANTIRETROVIRAL agents; HIV infections; THERAPEUTICS; DRUG toxicity
- Publication
Journal of Infectious Diseases, 2003, Vol 188, Issue 3, p388
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/376535