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- Title
Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) DNA sequences are absent in leukapheresis products and ex vivo expanded CD34[sup +] cells from multiple myeloma patients.
- Authors
De Greef, Catherine; Van De Voorde, Wendy; Bakkus, Marleen; Corthals, Jurgen; Heirman, Carlo; Schots, Rik; Lacor, Patrick; Van Camp, Ben; Van Riet, Ivan
- Abstract
Recently it was reported that Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) infects bone marrow (BM) dendritic cells (DC) in multiple myeloma (MM) patients and therefore might play a role in MM development. Because of the use of myeloid growth factors like GM-CSF and G-CSF for the mobilization of peripheral blood progenitor cells (PBPC), the subsequent increase of DC precursors might imply a risk for KSHV contamination in PBPC grafts. Therefore, in this study leukapheresis products and ex vivo cultured CD34+ cell suspensions were analysed. KSHV DNA could not be amplified in any of them.
- Subjects
HERPESVIRUSES; LEUKAPHERESIS; MULTIPLE myeloma
- Publication
British Journal of Haematology, 1999, Vol 106, Issue 4, p1033
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.1999.01628.x