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- Title
SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.
- Authors
Reitz, Christiane; Tokuhiro, Shinya; Clark, Lorraine N.; Conrad, Christopher; Vonsattel, Jean-Paul; Hazrati, Lili-Naz; Palotás, András; Lantigua, Raphael; Medrano, Martin; Z. Jiménez -Velázquez, Ivonne; Vardarajan, Badri; Simkin, Irene; Haines, Jonathan L.; Pericak -Vance, Margaret A.; Farrer, Lindsay A.; Lee, Joseph H.; Rogaeva, Ekaterina; George- Hyslop, Peter St.; Mayeux, Richard
- Abstract
The article presents a study on the role of Sortilin-related VPS10 domain containing receptor 1 (SORCS1) in Alzheimer's Disease (AD). The study explored the genetic associations of 16 SORCS1-single nucleotide polymorphisms (SNPs) to AD in independent data sets. Results reveal that the SORCS1 had influence the processing of amyloid precursor protein (APP). The study concludes that acquired or inherited changes in the expression of SORCs1 may have a role in AD pathogenesis.
- Subjects
GENETICS of Alzheimer's disease; AMYLOID beta-protein precursor; GENETIC polymorphisms; GENE expression; NUCLEOTIDES
- Publication
Annals of Neurology, 2011, Vol 69, Issue 1, p47
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.22308