We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Sweet Syndrome Associated with Active Inflammatory Bowel Disease: A Case Series of a Rare Extra-intestinal Manifestation.
- Authors
Sleiman, Joseph; Patel, Mihir; Khan, Muhammad Zarrar; Falloon, Katherine; Cohen, Benjamin; Click, Benjamin; Khanna, Urmi; Fernandez, Anthony P.; Rieder, Florian
- Abstract
Background: Cutaneous extra-intestinal manifestations (EIM) occur in up to 20% of patients with IBD. Information about Sweet syndrome (SS)'s clinical course as a rare cutaneous EIM in IBD is limited to case reports. We present the largest retrospective cohort on the occurrence and management of SS in IBD. Study: Electronic medical records and paper charts since 1980 were retrospectively reviewed at a large quaternary medical center to identify all adult IBD patients with histopathology-proven SS. Patient characteristics and clinical outcomes were evaluated. Results: 25 IBD patients with SS were identified; 3 patients were assessed to have AZA-induced SS. The majority of SS patients were female. Median age at diagnosis was 47 years (IQR 33–54 years) and SS appeared at a median of 6.4 years after IBD diagnosis. IBD patients with SS had a high rate of complicated IBD phenotypes (75% extensive colitis in UC and 73% stricturing or penetrating disease in CD, with 100% colonic involvement), as well as frequent co-occurring EIMs (60%). SS correlated with global IBD disease activity. Corticosteroids were an effective therapy for SS in IBD. Recurrence rate of SS was 36%. Conclusion: Contrary to previous case reports, SS was a cutaneous EIM occurring late after diagnosis of IBD in our cohort, with occurrences paralleling global IBD disease activity. Although AZA-induced and IBD-associated SS were both effectively treated with corticosteroids, distinguishing them is relevant for future IBD treatment strategies.
- Subjects
INFLAMMATORY bowel diseases; SWEET'S syndrome; ELECTRONIC health records; CUTANEOUS manifestations of general diseases; SEZARY syndrome; MUSIC charts; CELIAC disease
- Publication
Digestive Diseases & Sciences, 2023, Vol 68, Issue 9, p3562
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-023-07983-5