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- Title
Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study.
- Authors
Lim, Seon Hee; Kim, Nayoung; Kwon, Jin Won; Kim, Sung Eun; Baik, Gwang Ho; Lee, Ju Yup; Park, Kyung Sik; Shin, Jeong Eun; Song, Hyun Joo; Myung, Dae-Seong; Choi, Suck Chei; Kim, Hyun Jin; Lim, Joo Hyun; Yim, Jeong Yoon; Kim, Joo Sung
- Abstract
<bold>Background and Aim: </bold>Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population.<bold>Methods: </bold>Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria.<bold>Results: </bold>After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09-1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old.<bold>Conclusions: </bold>H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.
- Subjects
HELICOBACTER pylori infections; METABOLIC syndrome; HELICOBACTER pylori; BODY mass index; WAIST circumference; GASTRIC diseases
- Publication
Digestive Diseases & Sciences, 2019, Vol 64, Issue 8, p2219
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-019-05544-3