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- Title
In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis.
- Authors
Worthley SG; Zhang ZY; Machac J; Helft G; Tang C; Liew GY; Zaman AG; Worthley MI; Fayad ZA; Buchsbaum MS; Fuster V; Badimon JJ; Worthley, Stephen G; Zhang, Zhuang Y; Machac, Josef; Helft, Gérard; Tang, Cheuk; Liew, Gary Y H; Zaman, Azfar G; Worthley, Matthew I
- Abstract
We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 +/- 0.02 to 0.68 +/- 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 +/- 0.02 to 0.53 +/- 0.02, P < 0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model.
- Publication
International Journal of Cardiovascular Imaging, 2009, Vol 25, Issue 3, p251
- ISSN
1569-5794
- Publication type
journal article
- DOI
10.1007/s10554-008-9377-2