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- Title
Early Response of Specific IgE can Predict Satisfaction with Sublingual Immunotherapy.
- Authors
Kim, Jin Youp; Rhee, Chae‐Seo; Mun, Sue Jean; Cho, Seong H.; Lockey, Richard F.; Han, Doo Hee; Rhee, Chae-Seo
- Abstract
<bold>Objective: </bold>To investigate predictive parameters at baseline and during the early response to sublingual immunotherapy (SLIT) for house dust mites in allergic rhinitis patients.<bold>Study Design: </bold>Retrospective cohort study.<bold>Methods: </bold>Patients were treated with SLIT for at least 3 years and serological tests performed at baseline and at 1-year follow-up to investigate predictive parameters. Satisfaction with SLIT, 4 nasal symptoms, and quality of life were evaluated before and after 3 years of SLIT. Sixty-one patients were enrolled and divided into two groups depending on their satisfaction after 3 years of SLIT: 43 were satisfied (70.5%) and 18 were not (29.5%).<bold>Results: </bold>Immunological parameters at baseline did not differ significantly between the satisfactory and unsatisfactory groups. However, changes in both Dermatophagoides pteronyssinus (Dp)- and D. farinae (Df)-specific IgEs were significantly higher in the unsatisfactory group than in the satisfactory group during the early response to SLIT (P = .006 and P = .045, respectively).<bold>Conclusion: </bold>The changes in both Dp- and Df-specific IgE levels during early response may be indicators for favorable long-term treatment outcomes with SLIT. These results suggest that clinicians could measure these immunological parameters 1 year after Dp and Df SLIT to indicate potential responders versus nonresponders.<bold>Level Of Evidence: </bold>2b Laryngoscope, 131:467-472, 2021.
- Subjects
SUBLINGUAL immunotherapy; HOUSE dust mites; DERMATOPHAGOIDES pteronyssinus; MEDICAL personnel; SATISFACTION
- Publication
Laryngoscope, 2021, Vol 131, Issue 3, p467
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.28762