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- Title
Effects of Chinese Medicine on the Survival of AIDS Patients Administered Second-Line ART in Rural Areas of China: A Retrospective Cohort Study Based on Real-World Data.
- Authors
Jin, Yantao; Zhang, Miao; Ma, Yanmin; Sang, Feng; Li, Pengyu; Yang, Chunling; Wang, Dongli; Guo, Huijun; Liu, Zhibin; Xu, Qianlei
- Abstract
Objectives. Chinese medicine (CM) improves the symptoms of patients with acquired immune deficiency syndrome (AIDS) and prolongs their survival. This real-world study aimed to evaluate the effects of CM on the survival of AIDS patients administered second-line antiretroviral therapy (ART). Methods. We conducted a retrospective cohort study of the medical records of patients with AIDS who switched to second-line ART between January 2009 and December 2014. Patients were divided into ART and CM + ART groups. Propensity score matching (PSM) was performed to correct for biases between groups. Kaplan–Meier analysis and the log-rank test were used to compare survival rates, and Cox regression models were employed to identify factors significantly associated with survival. Results. The study population (n = 4180) was comprised of the CM + ART group (n = 855) and the ART group (n = 3325). After 1 : 2 PSM, 855 patients in the CM + ART group and 1699 in the ART group were selected for analysis. Patients in the CM + ART group were followed for 4246.8 person-years, and the mortality rate was 2.12/100 person-years. Patients in the ART group were followed for 8381.2 person-years, and the mortality rate was 2.91/100 person-years. Cox regression model analysis revealed that patients in the CM + ART group survived significantly longer than those in the ART group (hazard ratio: 0.73 and 95% confidence interval: 0.57–0.93). Gender, age, symptoms, CD4 cell counts, and viral loads were independently associated with the survival of AIDS patients treated with second-line ART. Conclusions. CM significantly improved the survival rate of AIDS patients treated with second-line ART.
- Subjects
CHINA; HERBAL medicine; CONFIDENCE intervals; COMBINATION drug therapy; RURAL conditions; LOG-rank test; AGE distribution; VIRAL load; CD4 antigen; ANTIRETROVIRAL agents; RETROSPECTIVE studies; COMPARATIVE studies; SEX distribution; SURVIVAL analysis (Biometry); KAPLAN-Meier estimator; AIDS; CHINESE medicine; AIDS patients; LONGITUDINAL method; PROBABILITY theory; PROPORTIONAL hazards models; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2022, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2022/5103768