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- Title
Phthalate's multiple hormonal effects and their supplementary dietary regulation scheme of health risks for children.
- Authors
Han, Zhenzhen; Xue, Jiaqi; Li, Yu
- Abstract
Four common phthalic acid esters (PAEs), namely, butylbenzyl phthalate (BBzP), dibutyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP), and di-n-octyl phthalate (DNOP) that are known to affect children upon exposure, were selected, and the hormone effects were explored during different supplementary food intakes by using methods such as factorial design experiment, molecular docking, and dynamics simulation techniques. A supplementary diet regulation scheme to prevent health risks of PAEs was constructed to avoid or mitigate the hormonal effects in children exposed to PAEs. Firstly, the MM/PBSA binding energy of PAEs with single hormone receptors and multiple hormone receptor complexes was calculated. In addition, 10 foods were selected as external interference conditions to carry out dynamic simulation, which showed that kiwi fruit and broccoli can effectively alleviate the PAEs' hormone effects. Furthermore, inference of the metabolic process of DEHP found that the supplementary diets could effectively promote the metabolism of PAEs. Finally, based on the mechanism analysis, it was confirmed that the selected supplementary diets could inhibit the binding process. This study aims to explore the role of supplementary diets in regulating various PAEs' hormone effects and thereby provide theoretical support for slowing down hormonal effects in children.
- Subjects
PHTHALATE esters; CHILDREN'S health; HORMONE receptors; BROCCOLI; DIBUTYL phthalate; KIWIFRUIT; MOLECULAR docking; FACTORIAL experiment designs
- Publication
Environmental Science & Pollution Research, 2022, Vol 29, Issue 19, p29016
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-021-17798-4