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- Title
Screening for Anti-tumor Activity of Fractions from Buddleja officinalis Maxim.
- Authors
Tong LI; Xin XIE; Liyuan LI; Aipeng LI; Zhidong LEI; Tingting HE; Sirui MO; Shangfeng HUANG; Yao LIN; Suoyi HUANG; Lixiang LU; Shiyou ZHOU
- Abstract
[Objectives] The anti-tumor activity of fractions from Buddleja qfficinalis Maxim, by petroleum ether, ethyl acetate, n-butanol and water solvent was studied. [Methods] The ethanol extract from B. qfficinalis Maxim, was extracted and then concentrated with petroleum ether, ethyl acetate, n-butanol and water, respectively, and the extracts were obtained. The inhibitory effects of the four different fractions on the growth of three tumor cell lines in vitro were detected by CCK-8 method, and the median inhibitory concentration (IC50 value) was calculated. [Results] The four fractions inhibited the growth of the three tumor cell lines in vitro, among which the n-butanol fraction had the best anti-tumor activity. The IC50 values of the n-butanol fraction on human gastric cancer (SGC-7901), human breast cancer (MCF-7) and human liver cancer (BEL-7404) cell lines were 0.08, 1.58 and 0.12 mg/mL, respectively. [Conclusions] Petroleum ether, ethyl acetate, n-butanol and water fractions from the ethanol extract of B. qfficinalis Maxim, had certain anti-tumor effects, and the n-butanol fraction had the best anti-tumor activity.
- Subjects
ETHYL acetate; ANTINEOPLASTIC agents; LIVER cancer; CELL lines; STOMACH cancer
- Publication
Medicinal Plant, 2024, Vol 15, Issue 2, p48
- ISSN
2152-3924
- Publication type
Article
- DOI
10.19600/j.cnki.issn2152-3924.2024.02.013