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- Title
Visualizing Odor Detection in Olfactory Cilia by Calcium Imaging<sup>a</sup>.
- Authors
LEINDERS-ZUFALL, TRESE; GREER, CHARLES A.; SHEPHERD, GORDON M.; ZUFALL, FRANK
- Abstract
ABSTRACT: To visualize odor detection in individual cilia of olfactory sensory neurons we have developed a new approach by using high-resolution calcium imaging techniques. Laser scanning confocal microscopy revealed, for the first time, that odor stimuli induce transient Ca2+ elevations in single olfactory cilia. Pharmacological analysis indicates that these Ca2+ signals depend entirely on Ca2+ entry through activated cyclic nucleotide-gated (CNG) channels. This novel approach enables us to monitor the initial steps leading to olfactory perception in a spatially and temporally resolved manner.
- Publication
Annals of the New York Academy of Sciences, 1998, Vol 855, Issue 1, p205
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1998.tb10567.x