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- Title
Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide.
- Authors
Burton, J. H.; Knych, H. K.; Stanley, S. D.; Rebhun, R. B.
- Abstract
Background Oral chemotherapy agents are frequently compounded in veterinary medicine however, the potency of some formulations have been shown to vary from that of Food and Drug Administration (FDA)-approved products. Aims The objective of this study was to evaluate the potency and stability of three compounded oral chemotherapeutics commonly prescribed to be administered over time. Materials & Methods Compounded chlorambucil 1 mg, cyclophosphamide 5 mg and melphalan 1 mg were obtained and for potency tested upon receipt and 6 weeks later. Results Potency ranged from 71 to 104% for chlorambucil and 58 to 109% for melphalan; 1/4 and 2/4 samples were <90% of labelled strength at baseline and 6 weeks, respectively, for both drugs. Potency of cyclophosphamide ranged from 92 to 107% with all samples +/−10% of labelled strength at all time points. Discussion/Conclusion These results demonstrate variability of compounded chemotherapy products, and highlight the need to consider both potency and stability when prescribing orally compounded chemotherapy.
- Subjects
ANTINEOPLASTIC agent testing; DOSAGE forms of drugs; DRUG stability; CYCLOPHOSPHAMIDE; CHLORAMBUCIL; MELPHALAN; CANCER chemotherapy
- Publication
Veterinary & Comparative Oncology, 2017, Vol 15, Issue 4, p1558
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12301