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- Title
Canine pancreatic islet cell tumours secreting insulin-like growth factor type 2: a rare entity.
- Authors
Finotello, R.; Ressel, L.; Arvigo, M.; Baroni, G.; Marchetti, V.; Romanelli, G.; Burrow, R.; Mignacca, D.; Blackwood, L.
- Abstract
Insulin-like growth factor type II ( IGF-II) is the main cause of non-islet cell tumour hypoglycaemia ( NICTH) and insulin is thought to be the only factor causing hypoglycaemia in insulinomas. However, two case reports of pancreatic neuroendocrine tumours ( PNETs) producing IGF-II have been previously published: a human and a canine patient. In this study, we investigated clinical, histopathological, immunohistochemical and ultrastructural features, and biological behaviour of canine pancreatic IGF-II-omas, a subgroup of PNETs that has not been previously characterized. Case records of 58 dogs with confirmed PNETs and hypoglycaemia were reviewed: six patients were affected by IGF-II-omas. Surgery was performed in all cases and two dogs had metastases. Four patients remained alive and in remission at 370, 440, 560 and 890 days post-diagnosis; two died of non-tumour-related causes. IGF-II-omas can be differentiated from insulinomas through hypoinsulinaemia, IGF-II positive and insulin negative immunostaining. The prevalence of this neoplasia is low, accounting for just 6% of PNETs.
- Subjects
ISLANDS of Langerhans tumors; SOMATOMEDIN A; HYPOGLYCEMIA; INSULINOMA; INSULIN research
- Publication
Veterinary & Comparative Oncology, 2016, Vol 14, Issue 2, p170
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12085