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- Title
A Prospective Study of Weight Gain in Women Diagnosed with Early-Stage Invasive Breast Cancer, Ductal Carcinoma In Situ, and Women Without Breast Cancer.
- Authors
Ekenga, Christine C.; Wang, Xiaoyan; Pérez, Maria; Schootman, Mario; Jeffe, Donna B.
- Abstract
Background: Weight gain after breast cancer has been associated with recurrence and mortality. We therefore examined factors associated with ≥5% weight gain over 2-year follow-up of a cohort of newly diagnosed early-stage invasive breast cancer (EIBC) and ductal carcinoma in situ (DCIS) patients and age-matched controls without a breast cancer history. Materials and Methods: We interviewed participants 4–6 weeks after definitive surgical treatment (patients) or a negative/benign screening mammogram (controls). Multivariable logistic regression models were used to identify socioeconomic, psychosocial, and treatment factors associated with ≥5% weight gain over 2-year follow-up. Results: Overall, 88 (24%) of 362 EIBC patients, 31 (17%) of 178 DCIS patients, and 82 (15%) of 541 controls had ≥5% weight gain during follow-up. EIBC patients were more likely to experience ≥5% weight gain than DCIS patients (Odds ratio [OR] = 2.16; 95% confidence interval [95% CI] = 1.19–3.95) and controls (OR = 1.76; 95% CI = 1.23–2.51). Among EIBC patients, older patients (OR = 0.96; 95% CI = 0.93–0.99), patients who underwent endocrine therapy (OR = 0.43; 95% CI = 0.19–0.95), smokers (OR = 0.35; 95% CI = 0.14–0.86), and African Americans (OR = 0.23; 95% CI = 0.09–0.58) were less likely to have ≥5% weight gain than their respective counterparts. Among DCIS patients, older patients (OR = 0.94; 95% CI = 0.89–0.99) were less likely to have ≥5% weight gain. Among controls, smokers were more likely to have ≥5% weight gain (OR = 3.03; 95% CI = 1.49–6.17). Conclusions: EIBC patients were more likely than DCIS patients and controls to experience ≥5% weight gain over follow-up. Studies are necessary to elucidate mechanisms of weight gain in early-stage breast cancer survivors.
- Subjects
BREAST tumor diagnosis; ADENOCARCINOMA; AGE distribution; BLACK people; BREAST tumors; CANCER patient psychology; CANCER invasiveness; COMPARATIVE studies; CONFIDENCE intervals; ESTROGEN receptors; HORMONES; PATIENT aftercare; INTERVIEWING; LONGITUDINAL method; SMOKING; THERAPEUTICS; TIME; TUMOR classification; WOMEN'S health; WEIGHT gain; MULTIPLE regression analysis; SOCIOECONOMIC factors; TREATMENT effectiveness; CARCINOMA in situ; PATIENTS' attitudes; DESCRIPTIVE statistics; EARLY detection of cancer; ODDS ratio
- Publication
Journal of Women's Health (15409996), 2020, Vol 29, Issue 4, p524
- ISSN
1540-9996
- Publication type
Article
- DOI
10.1089/jwh.2018.7638