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- Title
Ir‐SpinPHOX Catalyzed Enantioselective Hydrogenation of 3‐Ylidenephthalides.
- Authors
Ge, Yao; Han, Zhaobin; Wang, Zheng; Feng, Chen‐Guo; Zhao, Qian; Lin, Guo‐Qiang; Ding, Kuiling
- Abstract
Abstract: The first asymmetric hydrogenation of 3‐ylidenephthalides has been developed using the IrI complex of a spiro[4,4]‐1,6‐nonadiene‐based phosphine‐oxazoline ligand (SpinPHOX) as the catalyst, affording a wide variety of chiral 3‐substituted phthalides in excellent enantiomeric excesses (up to 98 % ee). The utility of the protocol has been demonstrated in the asymmetric synthesis of chiral drugs NBP and BZP precursor, as well as the natural products chuangxinol and typhaphthalide.
- Subjects
ENANTIOSELECTIVE catalysis; CATALYTIC hydrogenation; PHTHALIDES; ASYMMETRY (Chemistry); OXAZOLINE; LIGANDS (Chemistry)
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 40, p13324
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201807639