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- Title
A DNA Structure Containing Ag<sup>I</sup>-Mediated G:G and C:C Base Pairs.
- Authors
Liu, Hehua; Shen, Fusheng; Haruehanroengra, Phensinee; Yao, Qingqing; Cheng, Yunshan; Chen, Yiqing; Yang, Chun; Zhang, Jing; Wu, Baixing; Luo, Qiang; Cui, Ruixue; Li, Jixi; Ma, Jinbiao; Sheng, Jia; Gan, Jianhua
- Abstract
Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, AgI is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-AgI-C pairs and the first reported G-AgI-G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these AgI-mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA. This unique complex structure is highly sequence-dependent, thus implying functional potentials as a new DNA aptamer that can bind and recognize silver ions. These results not only advance our understanding of the interactions between AgI and nucleobases, but also provide a unique structural component for the rational design of new DNA nanodevices.
- Subjects
DNA structure; BASE pairs; CATIONS; HEAVY metals; APTAMERS
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 32, p9558
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201704891