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- Title
A β-Lactamase-Imprinted Responsive Hydrogel for the Treatment of Antibiotic-Resistant Bacteria.
- Authors
Li, Wen; Dong, Kai; Ren, Jinsong; Qu, Xiaogang
- Abstract
Antibiotics play important roles in infection treatment and prevention. However, the effectiveness of antibiotics is now threatened by the prevalence of drug-resistant bacteria. Furthermore, antibiotic abuse and residues in the environment cause serious health issues. In this study, a stimuli-responsive imprinted hydrogel was fabricated by using β-lactamase produced by bacteria for deactivating antibiotics as the template molecule. The imprinted hydrogel could initially trap β-lactamase excreted by drug-resistant bacteria, thus making bacteria sensitive to antibiotics. After the bactericidal treatment, the "imprinted sites" on the hydrogel could be reversibly abolished with a temperature stimulus, which resulted in the reactivation of β-lactamase to degrade antibiotic residues. We also present an example of the use of this antibacterial design to treat wound infection.
- Subjects
DRUG resistance in bacteria; HYDROGELS; ANTIBIOTICS; ENZYMES; MOLECULAR imprinting; BETA lactamases
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 28, p8181
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201600205