We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Actions of Kavain and Dihydromethysticin on Ipsapirone-Induced Field Potential Changes in the Hippocampus.
- Authors
Walden, Jörg; Von Wegerer, Jörg; Winter, Ute; Berger, M.
- Abstract
The kava-pyrones kavain and dihydromethysticin are constituents of Piper methysticum which possess muscle relaxant, anticonvulsant, analgesic and anxiolytic properties. In the present study the effect of both kava-pyrones were tested on field potential changes induced by the serotonin-1A agonist ipsapirone in the area CA1 and CA3 of the hippocampal slice preparation of guinea pigs. Ipsapirone induced positive field potential changes which were decreased in amplitude by the serotonin-1A antagonist NAN. The ipsapirone response was reduced by extracellular administration of kavain and dihydromethysticin in a dose-dependent manner down to 22·2 and 33·6%, respectively. It is suggested that kavain and dihydromethysticin modulate serotonin-1A receptor activity which may be of importance in the anti-anxiety action of kava-pyrones. © 1997 John Wiley & Sons, Ltd.
- Subjects
KAVA plant; TRANQUILIZING drugs; SEROTONIN; NEUROTRANSMITTERS; PSYCHIATRIC drugs
- Publication
Human Psychopharmacology: Clinical & Experimental, 1997, Vol 12, Issue 3, p265
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/(SICI)1099-1077(199705/06)12:3<265::AID-HUP872>3.0.CO;2-0