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- Title
Positive Anti-HIV ELISA Results in Pregnancy: Is It Reliable?
- Authors
Güler, Emrah; Arıkan, Ayşe; Abobakr, Mariam; Sayan, Murat; Süer, Kaya; Şanlıdağ, Tamer
- Abstract
<bold>Background: </bold>Human immunodeficiency virus (HIV) can be transmitted from mothers to their babies during pregnancy, delivery through vaginal fluids or breastfeeding. As false positivity anti-HIV results due to pregnancy could be detected and no relevant study have been reported in Northern Cyprus so far, we aimed to estimate the false anti-HIV positivity rate in pregnant women.<bold>Methods: </bold>A total of 11.977 women admitted to Near East University Hospital between 2015 and 2018 were involved. The fourth generation anti-HIV-1/2 ELISA test was carried out by chemiluminescence enzyme immunoassay. Positive results were confirmed by real-time polymerase chain reaction (rt-PCR). SPSS (Statistical Package for the Social Sciences) Demo Ver 22 program was used for statistical analysis and significance (p<0.05) was measured by Person Chi-Square and Fisher's Exact tests.<bold>Results: </bold>Anti-HIV-1/2 ELISA test was positive in 7 (0.3%) of pregnant and 11 (0.1%) of non-pregnant women. HIV RNA was not detected in any pregnant however, was detected in 2 (0.02%) of non pregnant. S/Co titer of pregnant and non pregnant who have positive anti-HIV-test without viral load was x̄=2.68±1.64 (1.34-5.20) and x̄=8.63±7.68 (1.56-20.98) respectively. False positivity was significantly higher in pregnants compared to non-pregnants (p=0.033).<bold>Conclusion: </bold>False positivity can be encountered during pregnancy therefore, positive anti-HIV-1/2 ELISA results should be confirmed with molecular techniques before initiating antiretroviral treatment.
- Subjects
NORTHERN Cyprus; HIV; PREGNANCY; CHEMILUMINESCENCE immunoassay; POLYMERASE chain reaction; ENZYME-linked immunosorbent assay
- Publication
Infectious Diseases in Obstetrics & Gynecology, 2022, p1
- ISSN
1064-7449
- Publication type
journal article
- DOI
10.1155/2022/1157793