We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt.
- Authors
Abdelaal, Azza; Abu-Elfatth, Ahmed; Bakkar, Lamees M.; El-Azeem, Hanan G. Abd; Hetta, Helal F.; Badawy, Eman R.
- Abstract
Background: Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome. Methods: The study included 106 COVID-19 patients, and 51 controls. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real-time PCR. In addition to baseline data and radiological findings, the coagulation profile was done with special attention to Fibrinogen, d-dimer, Factor VIII, von Willebrand factor (VWF), Protein C, Protein S, Antithrombin III (ATIII) and Lupus anticoagulant (LA)-1 and 2. Results: The results showed significantly higher VWF, d-dimer, and LA1 (screening) and LA2 (confirmation) in patients than a control group. Significantly higher d-dimer FVIII, VWF and LA1-2 were detected in the severe group. ATIII had high diagnostic accuracy in severity prediction. We found a significantly higher international randomized ratio (INR) and VWF among patients with thrombotic events. For prediction of thrombosis; VWF at cutoff > 257.7 has 83.3% sensitivity and 83.3% specificity. Conclusion: Patients with COVID-19 infection are vulnerable to different forms of coagulopathy. This could be associated with poor outcomes. d-Dimer is a chief tool in diagnosis, severity evaluation but not thrombosis prediction. Early screening for this complication and its proper management would improve the outcome.
- Subjects
EGYPT; REVERSE transcriptase polymerase chain reaction; COVID-19; RNA; TREATMENT effectiveness; BLOOD coagulation disorders; FIBRINOGEN; RESEARCH funding; HEMOSTATICS; BLOOD coagulation factors; SENSITIVITY &; specificity (Statistics); FIBRIN fibrinogen degradation products; DISEASE risk factors
- Publication
Infection, 2023, Vol 51, Issue 3, p655
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-022-01917-5