We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Virulence of beta-hemolytic streptococci in infective endocarditis.
- Authors
Ruch, Yvon; Hansmann, Yves; Riegel, Philippe; Lefebvre, Nicolas; Mazzucotelli, Jean-Philippe; Douiri, Nawal; Martin, Aurélie; Argemi, Xavier
- Abstract
Background: Streptococci involved in infective endocarditis (IE) primarily comprise alpha- or non-hemolytic streptococci (ANHS). Moreover, beta-hemolytic streptococci (BHS) can be involved, and guidelines recommend the addition of gentamicin for the first 2 weeks of treatment and the consideration of early surgery in such cases. This study compared the morbidity and mortality associated with IE depending on the microorganisms involved (BHS, ANHS, staphylococci, and enterococci). Methods: We conducted a retrospective observational study between 2012 and 2017 in a single hospital in France. The endpoints were overall in-hospital mortality, 1-year mortality and the occurrence of complications. Results: We analyzed 316 episodes of definite IE including 150 (38%), 96 (25%), 46 (12%), and 24 cases (6%) of staphylococcal, ANHS, enterococcal, and BHS IE, respectively. In-hospital mortality was significantly higher in the staphylococcal (n = 40; 26.7%) and BHS groups (n = 6; 25.0%) than in the ANHS (n = 9; 9.4%) and enterococcal groups (n = 5; 10.9%) (all p < 0.01). The rates of septic shock and cerebral emboli were also higher in the BHS group than in the ANHS group [n = 7 (29.2%) vs. n = 3 (3.1%), p < 0.001; n = 7 (29.2%) vs. n = 12 (12.5%); p = 0.05, respectively]. Conclusion: This study confirmed that BHS IE has a more severe prognosis than ANHS IE. The virulence of BHS may be similar to that of staphylococci, justifying increased monitoring of these patients and more 'aggressive' treatments such as early surgery.
- Subjects
FRANCE; ENDOCARDITIS; CEREBRAL embolism &; thrombosis; DISEASES; ENTEROCOCCUS; CARDIAC surgery; HOSPITALS; SCIENTIFIC observation; SEPTIC shock; STAPHYLOCOCCAL diseases; STAPHYLOCOCCUS; STREPTOCOCCAL diseases; STREPTOCOCCUS; MICROBIAL virulence; ENTEROCOCCAL infections; RETROSPECTIVE studies; DESCRIPTIVE statistics; HOSPITAL mortality; DISEASE complications
- Publication
Infection, 2020, Vol 48, Issue 1, p91
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-019-01358-7